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Anadrol Review- What Is Anadrol, Its Benefits & Side Effects

What Is Anadrol

What is Anadrol?

Anadrol (often referred to as “A50” or “A-bombs” by athletes) was originally intended to assist those suffering from anemia, but it has subsequently been used extremely effectively to aid persons suffering from a variety of different ailments where weight loss is an issue. As a result, it is unquestionably an excellent agent for encouraging weight growth, increasing hunger, enhancing strength, and raising Red Blood Cell count. Aside from that, it has the same drawbacks as the majority of anabolic/androgenic steroids (AAS). Inhibiting your body’s natural hormone production (testosterone, estrogen, and so on), Anadrol 50 will have a bad impact on your blood lipid profile, may induce water retention, is known for creating headaches, and is very toxic to your liver, among other things (in fact, it has the worst reputation for hepatoxicity out of all steroids). Ironically, despite the fact that it is marketed by its original maker (Syntex) as having the ability to encourage weight gain via increased hunger, consuming too much of it may actually suppress your appetite!

The Effects of Anadrol on the Body

Anadrol effects

I believe that in order to acquire a thorough grasp of Anadrol 50’s effects on the body, we must first examine its benefits in comparison to its drawbacks. Anadrol 50 is an anabolic steroid. Anadrol is a DHT-derived chemical that is a 17-Alpha-Alkylated steroid, which means that it has had its carbon atoms at the 17th position changed in order to withstand oral intake. The majority of oral steroids are 17aa, which allows them to pass through your liver in a usable form more easily. That sounds fantastic, does not it? Let us make everything 17alpha-alkylate! As you may expect, there is a negative aspect to this.

Anadrol Adverse Reactions

In addition to making it possible for Anadrol to survive its initial trip through your liver, this 17aa change makes Anadrol an extremely demanding substance for your liver. How demanding is Anadrol, and how much weight can you expect to acquire as a result of using it? An Anadrol research was carried out for a period of 30 weeks, during which time a respectable number of adverse effects were observed, as you could anticipate. The notion that Anadrol may induce certain adverse effects has never really been contested in any way. But how successful was the medicine in the long run? First and first, it should be noted that this research was conducted on persons suffering from AIDS-related wasting, and they actually gained weight (8+kg), while the control group lost weight and saw higher death rates. Perhaps if you are participating in research because you have a wasting disease that is also a fatal condition, you do not want to be assigned to the control group. I believe this is the case. The weight growth in this research, on the other hand, peaked at 19-20 weeks, meaning that the remaining 10 weeks were not very fruitful in this regard. Given the toxicity of Anadrol 50, it is obvious that you would not want to use it for more than 20 weeks at a time. However, beyond that, any influence on weight and strength increases would be minor. The fact that this trial ran for such a long period of time (30 weeks) should have shown that side effects from Anadrol can be controlled and that the medicine may be administered without risk of adverse effects being experienced. People are often advised to restrict their consumption of Anadrol to no more than 4 weeks at a time. I am a little less cautious, and I believe you should be able to run Anadrol for at least six weeks.

However, based on my own personal experience, I can tell you that increases in Anadrol are rather impressive for the first three weeks, after which they swiftly plateau. In my experience, the adverse effects associated with Anadrol (which for me include a headache, bloating, raised blood pressure, and an overall sense of “unwell”) last the whole time I am taking the medication, despite my best efforts to stop using it. However, as is often the case, I find that the adverse effects of this medication are a mixture of urban rumor and reality. Because Anadrol 50 is formed from DHT, it cannot be converted into estrogen (through the aromatase enzyme), and because it is neither a progestin nor a substance with progestogenic action, the estrogenic adverse effects induced by it are quite puzzling. Theorists have theorized that it may be able to activate the estrogen receptor without actually converting to estrogen, and it is probably the most convincing explanation I have heard so far. However, when Oxymetholone has been employed in research to change the female reproductive/menstrual cycle, the results have been bizarre; in such studies, it has been shown to reduce plasma progesterone levels! Although it would seem that an AI (aromatase inhibitor) would be of little benefit with this medication, many people have discovered that Letrozole (which has been shown to reduce estrogen levels in the body to undetectable levels in some cases)(6) can significantly reduce or even eliminate many of the more noticeable side effects of Anadrol, such as bloating.

As previously indicated, however, the negative effects of this medication are not to be taken lightly; yet, they are readily prevented and manageable. One research even found that patients taking up to 100mgs of Oxymetholone had very minimal negative effects. Dan Duchaine, the author of the original UnderGround Steroid Handbook, claims to have taken it at levels of up to 150mgs per day. In certain quarters, the hepatotoxicity of Anadrol has been overstated, which is understandable. Regardless, my recommendation is to keep Anadrol usage to a maximum of 6 weeks, even if it is only to be on the safe side and avoid any negative side effects. Of course, I have personally used this medication for a considerably longer period of time.

What is the best way to utilize Anadrol? I would be prepared to incorporate Anadrol in a cycle that included injectable steroids, but I would not consider introducing any other 17aa substances. I would recommend starting any 6-week run of this compound at the beginning of a cycle as a way to “jumpstart” the process of seeing improvements as fast as possible. The rapid gains you will see while using Anadrol (up to a pound per day for the first two weeks is not unusual among users) will also be just as rapid to decrease after you stop using it. Unless, of course, you are merely utilizing it as a kicker while you wait for the effects of the other substances to take effect. I am going to go out on a limb here and say that using Anadrol as a “Jumpstart” is the most common way for athletes and bodybuilders to utilize this steroid today, and I am not wrong. I would also mention that this substance is very popular among strength athletes who do not have to worry about competing in weight classes (such as field athletes and strongmen), as well as powerlifters competing in the larger weight classes (such as Olympic lifters). Furthermore, it is worth noting that according to one study conducted by Schroder et al, Anadrol has the ability to lower serum SHBG (Sex Hormone Binding Globulin, which binds to your free test and renders it ineffective for anabolism, among other things) concentrations by 54.9 25.8 and 45 16.2 nmol/l in the 50- and 100-mg treatment groups, respectively, compared to the control group. This implies that when you take this medicine, there will be more free testosterone circulating throughout your body, which will, undoubtedly, cause some synergy when combined with other anabolic steroids. Because of the substantial quantities of weight and strength that may be acquired in a very short period of time when using this medication, I am sure this comes as no surprise to many.

The fact that Oxymetholone does not bind effectively to the androgen receptor (Relative Binding Affinity = too low to be measured) is another crucial and frequently overlooked aspect of this substance. This is the lowest relative binding affinity I have ever heard about. Essentially, what this tells me is that this steroid has a large number of non-receptor mediated effects, which makes it an extremely effective addition to ANY BULKING stack since it will not be fighting for receptor sites with the other steroids you are taking. Furthermore, as you would expect, it is a really terrible option for a cutting stack.

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Anadrol Cycles

Anadrol Cycles

What exactly is the Anadrol Cycle? How much should you put into it? This is really one of the most intriguing facts regarding Anadrol 50, and it is worth noting. See, most steroids generate what is known as a “dose respondent curve,” which is a fancy way of stating that the more you take, the more you get.

Among the few anabolic steroids, Anadrol has a dosage response curve that flattens out fairly early. When you take 50mgs of Anadrol, you will see significant improvements in muscle mass. Take 100mgs of Anadrol and you will see even greater improvements in muscle mass. Although it has been shown that 100 mg/day is just as effective for weight growth as 150 mg/day, it has been discovered that it creates fewer negative effects and is less hazardous. I believe that the increase in benefit relative to cost from 50mgs to 100mgs is an acceptable increase, but this is not the case when the dose is more than 100mgs. To demonstrate how 50mg and 100mg of Oxymetholone genuinely affect strength when compared to one another, consider the following:

The percentage changes in strength for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (open bars) are displayed (gray bars). The numbers in the top bars show the percentage change (from baseline to week 12) in 1-repetition maximal strength testing from baseline to week 12. The error bars reflect one standard error of the mean. P 0.05 indicated a statistically significant difference from placebo; P 0.02 indicated a statistically significant difference from placebo by Wilcoxon test. Additional statistical analyses are provided in the text.

As you can see from the results of this research, increasing the dosage of Anadrol 50 by a factor of roughly two practically doubled the strength gains of the test participants. We can see that when we look at changes in body composition as a result of Oxymetholone (see chart below), although the guys taking 100mgs (as opposed to the 50mgs group) experienced significantly more fat loss and significantly more Lean Body Mass gain, the differences were not as dramatic as the differences in strength gains between the two groups:

Graphs depicting changes in body composition in the groups that received a placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (filled bars) (gray bars). The numbers above the bars reflect the mean absolute changes, while the error bars represent one standard error of the mean. The differences between the three groups were statistically significant (P 0.0001, one-way ANOVA) in terms of total lean body mass (LBM) and total fat. There were statistically significant changes from the placebo (P 0.001).

Even while I am not normally willing to speculate on the reasons why a certain medicine does or does not accomplish anything, in this particular instance I will. I am presuming that the larger dosages of Anadrol create enough appetite suppression (at least according to anecdotal evidence) to make eating a challenging task. It has also been shown to promote insulin resistance and glucose intolerance in certain people. Because of this, macronutrient absorption becomes less efficient, and gains may be reduced when the dose is more than 100mg/day, which may be a contributing reason to decreased growth. Unfortunately, Anadrol has a moderately negative impact on your body’s natural hormonal system, on par with most other oral steroids but not as bad as most injectables, and it is certainly not as detrimental to your lipid profile as many anabolic steroids are. Anadrol is also relatively safe for use in women.

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Anadrol for Muscle Building

Anadrol for Muscle Building

Also, as a fascinating side note, according to some medical literature on this substance, a dosage of 1-5mgs per kg of body weight should be administered. I will stop for a moment to let you calculate how insanely high of dosage it would be for the typical bodybuilder to get!

These steroids are readily accessible on the black market in a variety of forms, including capsules, tablets (some of which contain 75mg of testosterone), liquid, and even paper. Prices may vary and will be influenced by a variety of variables, including the form in which you purchase this compound (paper will typically be the most costly and liquid the least expensive), as well as your geographic location. In any event, you should not have to spend more than $2.50-3.00 for a 50mg dose of medication.

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